American Melody
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
Mississippi River cruises
- 579
- sailings on our books
- $3,499
- lowest fare per guest, confirmed at quote
- 7–22
- nights
Mississippi River
Sails from
Chattanooga · Louisville · Memphis · Nashville · New Orleans · Pittsburgh · St. Louis · St. Paul
Ports on these itineraries
Alton · Baton Rouge · Burlington · Cape Girardeau · Chattanooga · Cincinnati · Clarksville · Cleveland · Darrow · Davenport · Decatur · Dover · Dubuque · Florence · Greenville · Hannibal · Henderson · Huntsville · La Crosse · Louisville · Madison · Marietta · Maysville · Memphis · Muscatine · Nashville · Natchez · New Orleans · Oak Alley · Oak Alley/Houmas House · Owensboro · Paducah · Pittsburgh · Quad Cities · Red Wing · Savannah · St. Francisville · St. Louis · St. Paul · Tunica · Vicksburg · Wheeling · Winona
Every Mississippi River sailing we track
American Serenade
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Melody
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Heritage
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Splendor
nicko cruises
Zauber des Old Man Rivers
nicko cruises · 12 nights · New Orleans
Request a quote
American Splendor
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Melody
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Heritage
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Serenade
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Heritage
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Splendor
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Heritage
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Symphony
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Melody
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Heritage
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Serenade
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Splendor
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Heritage
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Melody
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Heritage
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Serenade
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Heritage
American Cruise Lines
Highlights of the Mississippi Cruise
American Cruise Lines · 7 nights · New Orleans
Request a quote
American Splendor
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
American Melody
American Cruise Lines
Lower Mississippi River Cruise
American Cruise Lines · 8 nights · New Orleans
Request a quote
Not sure which Mississippi River itinerary?
They vary more than the listings suggest — some are port-heavy, some are half sea days, and the right answer depends on who is travelling. Tell an advisor what you want and they will narrow it down.
Ask an advisor